백서의 타액선에서 BMP-2, BMP-4, FGF-7, IGF-1 및 TGF-α의 발현 양상에 관한 연구
Expression of BMP-2, BMP-4, FGF-7, IGF-1, and TGF-α in the Salivary Gland of Mouse
구승준, 장영일, 김성곤, 김좌영, 김영희, 채창훈, 김명희, 최재용,
소속 상세정보
구승준 ( Ku Seung-Jun ) - 서울대학교 치과대학 치과교정학교실
장영일 ( Chang Yong-Il ) - 서울대학교 치과대학 치과교정학교실
김성곤 ( Kim Seong-Gon ) - 한림대학교 성심병원 구강악안면외과학교실
김좌영 ( Kim Jwa-Young ) - 한림대학교 성심병원 구강악안면외과학교실
김영희 ( Kim Young-Hee ) - 한림대학교 성심병원 구강악안면외과학교실
채창훈 ( Chae Chang-Hoon ) - 한림대학교 의과대학 구강악안면외과학교실
김명희 ( Kim Myung-Hee ) - 가야치과병원
최재용 ( Choi Jae-Yong ) - 경북대학교 의과대학 생화학교실
KMID : 1138320060020020083
Abstract
The salivary gland is a source of saliva and it contains many kinds of growth factors. Among them, we studied the localization of TGF-α, IGF-1, FGF-7, BMP-2 and BMP-4 in mouse using immunohistochemistry and in-situ hybridization. BMP-2 was found in myoepithelial cells of the parotid gland. BMP-4 was found in the acinar cells of both parotid gland and submandibular gland. FGF-7 was found in the capillary endothelial cells and the myoepithelial cells of the parotid gland and IGF-1 was found in the excretory duct cells of both parotid gland and submandibular gland. TGF-α was found in the capillary endothelial cells and the myoepithelial cells of the submandibular gland. Collectively, many growth factors were found in the salivary gland and they were important to maintain the homeostasis and the wound healing of the oral cavity.
키워드
BMP;FGF;IGF;Salivary gland
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